کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1360305 | 981433 | 2010 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and anti-HIV evaluation of water-soluble calixarene-based bithiazolyl podands Synthesis and anti-HIV evaluation of water-soluble calixarene-based bithiazolyl podands](/preview/png/1360305.png)
Nine anionic water-soluble calix[4]arene species, incorporating sulfonate, carboxylate or phosphonate groups, six of them incorporating two 2,2′-bithiazole subunits in alternate position at the lower rim, have been synthesised and evaluated as anti-HIV agents on various HIV strains and cells of the lymphocytic lineage (HIV-1 III B/MT4, HIV-1 LAI/CEM-SS, HIV-1 Bal/PBMC), using AZT as reference compound. A toxicity was detected for a minority of compounds on PBMC whereas for the others no cellular toxicity was measured at concentrations up to 100 μM. Most of the compounds have an antiviral activity in a 10–50 μM range, and one of them, sulfonylated, displays its activity, whatever the tropism of the virus, at a micromolar concentration.
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Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 1, 1 January 2010, Pages 36–45