Aminopyridinecarboxamide-based inhibitors: Structure–activity relationship

Series of aminopyridinecarboxamide-based inhibitors were synthesized and tested against human recombinant IKK-2 and in IL-1β stimulated synovial fibroblasts. The 2-amino-5-chloropyridine-4-carboxamides were identified as the most potent inhibitors with improved cellular activity.

Aminopyridinecarboxamide-based iKK-2 inhibitors were synthesized and tested leading to the 2-amino-5-chloropyridine-4-carboxamides as potent inhibitors with improved cellular activity.Figure optionsDownload as PowerPoint slide