کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1360348 981433 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs
چکیده انگلیسی

As part of ongoing studies in developing new antimicrobials, a class of structurally novel 4-thiazolidinone derivatives incorporating three known bioactive nuclei such as thiazole, thiazolidinone and adamantane was synthesized by the multi-step reaction protocol, already reported in the literature. NMR and Molecular Modeling techniques were employed for structure elucidation and Z/E potential isomerism configuration of the analogues. Evaluation of antibacterial and antifungal activity showed that almost all compounds exhibited better results than reference drugs thus they could be promising candidates for novel drugs.

A series of 4-adamantyl-2-thiazolylimino-5-arylidene-4-thiazolidinones were synthesized in a four steps reaction and tested for their antifungal and antimicrobial activities.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 1, 1 January 2010, Pages 426–432
نویسندگان
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