Synthesis of all-trans anandamide: A substrate for fatty acid amide hydrolase with dual effects on rabbit platelet activation

The first synthesis of all-trans anandamide is reported together with its effects on FAAH and rabbit platelet aggregation. The all-trans PUFA approach can represent an antisense strategy in a chemical biology approach focusing on the trans geometry, which is the opposite of the cis configuration present in the natural lipids.