کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1360422 | 981435 | 2011 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Potent inhibition of Norwalk virus by cyclic sulfamide derivatives Potent inhibition of Norwalk virus by cyclic sulfamide derivatives](/preview/png/1360422.png)
A new class of compounds that exhibit anti-norovirus activity in a cell-based system and embody in their structure a cyclosulfamide scaffold has been identified. The structure of the initial hit (compound 2a, ED50 4 μM, TD50 50 μM) has been prospected by exploiting multiple points of diversity and generating appropriate structure–activity relationships.
A new class of compounds that exhibit anti-norovirus activity in a cell-based system and embody in their structure a cyclosulfamide scaffold, has been identified. The structure of the initial hit (compound 2a (structure (I) where R = H), ED50 4 μM, TD50 50 μM) has been prospected by exploiting multiple points of diversity and generating appropriate structure–activity relationships.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 20, 15 October 2011, Pages 5975–5983