کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1360531 | 981438 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hybridization-dependent fluorescence of oligodeoxynucleotides incorporating new pyrene-modified adenosine residues
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
We report the synthesis and properties of oligonucleotides incorporating N6-[N-(pyren-1-ylmethyl)carbamoyl]-deoxyadenosine (dApymcm). We designed the ODN which incorporated two consecutive dApymcm residues. It was revealed that on hybridization with the target DNA and RNA oligomers, the fluorescence spectra of ODNs having two consecutive dApymcm molecules near the 5′-terminal position can change from the pyrene monomer emission to the excimer, depending on the chain length of the target DNA and RNA. These results indicated that dApymcm-modified ODNs can be used as interesting hybridization sensors that are sensitive to the size of the target strand.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 17, 1 September 2008, Pages 8287–8293
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 17, 1 September 2008, Pages 8287–8293
نویسندگان
Kohji Seio, Masanhiro Mizuta, Kaori Tasaki, Keigo Tamaki, Akihiro Ohkubo, Mitsuo Sekine,