کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1360580 | 981441 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter](/preview/png/1360580.png)
چکیده انگلیسی
The synthesis and structure–activity relationship of a new class of indole derivatives with low-nanomolar affinity for the SERT and high selectivity versus the 5-HT1A receptor were recently reported. Based on their chemical structure, four new indolylpropylamine derivatives which contain atoms to afford future labeling with PET isotopes, were synthesized and evaluated as SERT ligands. The chemistry of these novel derivatives, their biological evaluation, the general method of preparing the precursor indole for labeling, and the C-11 labeling of the most promising indole derivative, are described herein.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 12, 15 June 2008, Pages 6364–6370
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 12, 15 June 2008, Pages 6364–6370
نویسندگان
R. Ben-Daniel, W. Deuther-Conrad, M. Scheunemann, J. Steinbach, P. Brust, E. Mishani,