کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1360603 | 981442 | 2009 | 12 صفحه PDF | دانلود رایگان |

A series of simplified thiomarinol derivatives was prepared by way of catalytic enantioselective inverse electron demand hetero [4 + 2] cycloaddition/allylboration tandem reaction. As a preliminary evaluation, these analogs were tested for antimicrobial activity using a standard disk diffusion assay. Whereas amide analogs were less active, the simple ester analogs 3 and 4 were demonstrated to be more active than thiomarinol H.
Simplified derivatives of the thiomarinol class of antibiotics were prepared via a catalytic enantioselective inverse electron demand hetero [4 + 2] cycloaddition/allylboration tandem reaction. These analogs were tested for antimicrobial activity using a standard disk diffusion assay.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 3, 1 February 2009, Pages 1006–1017