کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1360603 981442 2009 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and preliminary antibacterial evaluation of simplified thiomarinol analogs
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and preliminary antibacterial evaluation of simplified thiomarinol analogs
چکیده انگلیسی

A series of simplified thiomarinol derivatives was prepared by way of catalytic enantioselective inverse electron demand hetero [4 + 2] cycloaddition/allylboration tandem reaction. As a preliminary evaluation, these analogs were tested for antimicrobial activity using a standard disk diffusion assay. Whereas amide analogs were less active, the simple ester analogs 3 and 4 were demonstrated to be more active than thiomarinol H.

Simplified derivatives of the thiomarinol class of antibiotics were prepared via a catalytic enantioselective inverse electron demand hetero [4 + 2] cycloaddition/allylboration tandem reaction. These analogs were tested for antimicrobial activity using a standard disk diffusion assay.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 3, 1 February 2009, Pages 1006–1017
نویسندگان
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