کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1360642 | 981442 | 2009 | 8 صفحه PDF | دانلود رایگان |

A series of xanthone derivatives were synthesized and examined for electrocardiographic, antiarrhythmic, hypotensive and anticonvulsant activities as well as for α1- and β1-adrenergic binding affinities. Among the investigated compounds, some of them exhibited significant antiarrhythmic and/or hypotensive activity. The data obtained via receptor binding assay are in agreement with pharmacological results and could explain antiarrhythmic and/or hypotensive activity of the newly synthesized structures.
Selected xanthone derivatives, expected to reveal cardiovascular properties, were synthesized and tested for their antiarrhythmic, antihypertensive and anticonvulsive activity, as well as for the α1- and β1-adrenoceptor binding affinities.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 3, 1 February 2009, Pages 1345–1352