Synthesis of highly deuterium-labeled (R)-K-13675, PPAR α agonist, for use as an internal standard for low-level quantification of drugs in plasma

Two highly deuterium-labeled compounds, (R)-K-13675-d11 and (R)-K-13675-d7, were prepared for use as internal standards for low-level quantification of plasma drugs by LC/MS/MS. We successfully demonstrated their utility in pharmacokinetic studies for sensitive and precise drug quantification.

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