کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1360726 | 981446 | 2008 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Genotoxicity of α-asarone analogues Genotoxicity of α-asarone analogues](/preview/png/1360726.png)
The role of cholesterol in the formation of atherosclerotic lesions during hypercholesterolemia has been confirmed. α-Asarone is a substance of a potent hypolipidemic activity which is isolated from plants. We previously described the synthesis of several α-asarone analogues exhibiting hypolipidemic and antiplatelet activity. Genotoxic activity of four selected α-asarone analogues was theoretically evaluated based on quantum-mechanical method for calculation of enthalpy of carbocations formation (ΔHR) according to the Testa’s method. In the present paper, we evaluated the mutagenic and genotoxic activity of α-asarone isomers 2–5 based on the reference Ames test and micronucleus test. Results obtained in the study show that tested isomers were non-mutagenic, however, they exhibited growing cytotoxic activity. Relationship between the heat of formation of their putative metabolic intermediates and mutagenic/genotoxic activity was not confirmed.
α-Asarone isolated from plants express hypolipidemic activity. In the present paper, we evaluated mutagenic and genotoxic activity of four α-asarone isomers based on the reference Ames test and micronucleus test.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 11, 1 June 2008, Pages 6069–6074