کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1360738 981446 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Isolation and antimalarial activity of new morphinan alkaloids on Plasmodium yoelii liver stage
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Isolation and antimalarial activity of new morphinan alkaloids on Plasmodium yoelii liver stage
چکیده انگلیسی

Decoction of Strychnopsis thouarsii is used in the Malagasy traditional medicine to combat malaria. We have shown that this traditional remedy prevents malaria infection by targeting Plasmodium at its early liver stage. Bioassay-guided fractionation of S. thouarsii stem barks extracts, using a rodent Plasmodium yoelii liver stage parasites inhibition assay, led to isolate the new morphinan alkaloid tazopsine (1) together with sinococuline (2) and two other new related morphinan analogs, 10-epi-tazopsine (3) and 10-epi-tazoside (4). Structures were characterized by 2D NMR, MS, and CD spectral analysis. Compounds 1–3 were found to fully inhibit the rodent P. yoelii liver stage parasites in vitro.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 11, 1 June 2008, Pages 6186–6192
نویسندگان
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