Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials

A highly atom economic one pot synthesis of tetrahydropyridines was achieved by l-proline/TFA catalysed multicomponent reaction of β-keto-esters, aromatic aldehydes and anilines. The synthesized compounds were screened against Plasmodiumfalciparum in vitro and one of them showed antimalarial activity with MIC as low as 0.09 μg/mL.

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