کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1360818 981448 2009 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, biological evaluation and quantitative structure-activities relationship of flavonoids as vasorelaxant agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, biological evaluation and quantitative structure-activities relationship of flavonoids as vasorelaxant agents
چکیده انگلیسی

A series of flavonoid derivatives were designed, synthesized. Their vasorelaxant activities were evaluated experimentally against rat aorta rings pretreated with phenylephrine (PE). Among them, 6-hydroxy-8-allyl-4′-chloro-flavanone 8q exhibited the highest vasodilatory activity (EC50 = 4.6 μM, Emax = 95.1%). The 3D-QSAR analysis was carried out by comparative molecular field analysis (CoMFA) method, and a statistically reliable model with good predictive power (r2 = 0.872 and qcv2 = 0.496) was established. The contour plots of CoMFA model provide a good insight into the structure-activity relationships of these compounds and may be used to design more potent flavonoids derivatives as vasorelaxant agents.

A series of flavonoid derivatives were designed, synthesized as vasorelaxant agents. Some were found to possess potent vasorelaxant activity. CoMFA analysis was carried out, and a statistically reliable QSAR model (r2 = 0.872 and q2 = 0.496) was established.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 2, 15 January 2009, Pages 716–726
نویسندگان
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