کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1360831 | 981448 | 2009 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action](/preview/png/1360831.png)
Nineteen ursolic acid derivatives (15 novel compounds) modified at the C-3 and the C-28 positions were synthesized. The cytotoxic activity of the derivatives was evaluated against HeLa, BGC-823 and SKOV3 cells by MTT assay. Inducing apoptosis and affecting cell cycle distribution by the derivatives in HeLa cells were assessed by flow cytometry and DNA fragmentation. Compounds 10b and 11b were particularly active to inhibit HeLa cells growth through inducing apoptosis and arresting cell cycle progression. The typical ‘sub-G1 peak’ and DNA ladder formation were checked and cell cycle was arrested at the S phase in a dose-dependent manner.
The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their inducing apoptosis and affecting cell cycle distribution are reported.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 2, 15 January 2009, Pages 848–854