کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1360856 981451 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and synthesis of dinucleotide 5′-triphosphates with expanded functionality
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design and synthesis of dinucleotide 5′-triphosphates with expanded functionality
چکیده انگلیسی

We propose the new approach to the synthesis of 5′-triphosphate derivatives of natural and modified dinucleotides with expanded functionality. Our strategy includes the combination of the solution phase synthesis of necessary dimers using the wide range of nucleic acids chemistry methods and the subsequent introduction of the triphosphate residue. A number of the new potential substrates for the template dependent synthesis of nucleic acids with expanded functionality are obtained, namely, 5′-triphosphates of dinucleotides containing the functionally active groups in heterocyclic bases, in carbohydrate–phosphate backbone, and the groups mimicking the residues of natural amino acids. The abilities of the proposed synthetic route are also demonstrated by the synthesis of 5′-triphosphates of dinucleotides with modified carbohydrate–phosphate backbone.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 20, 15 October 2008, Pages 9127–9132
نویسندگان
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