کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1360894 981452 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents
چکیده انگلیسی

Some new substituted coumarinylthiazolines, coumarinylthiazolidin-4-ones, and substituted chromenothiazoles were synthesized and evaluated for anticonvulsant activity. Some selected compounds were assayed against seizures induced by pentylenetetrazole (PTZ) and strychnine in mice. Compounds 3b, 6b, and 7b were the most active of the series against PTZ induced seizures. Compound 7b provided anticonvulsant activity (PD50 = 95 mg/kg, ip) at a dose 200 mg/kg compared to phenobarbital (PD50 = 16 mg/kg, ip) at a dose 30 mg/kg (90% protection). No clear correlation was observed between the antiepileptic activity and molecular lipophilicity descriptors of the tested compounds.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 10, 15 May 2008, Pages 5377–5388
نویسندگان
, , ,