کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1360913 | 981452 | 2008 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of indirubin-N′-glycosides and their anti-proliferative activity against human cancer cell lines
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of indirubin-N′-glycosides and their anti-proliferative activity against human cancer cell lines Synthesis of indirubin-N′-glycosides and their anti-proliferative activity against human cancer cell lines](/preview/png/1360913.png)
چکیده انگلیسی
The first indirubin-N′-glycosides were prepared based on reactions of isatin-N′-glycosides with indoxyls. The products show a significant anti-proliferative activity against various human cancer cell lines. Good results were observed for an indirubin-N′-mannoside which was shown to have medium to high anti-proliferative activity against all investigated cell lines. The highest activities and selectivities against the MCF-7 breast cancer cell line were observed for indirubin-N′-rhamnosides.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 10, 15 May 2008, Pages 5570–5583
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 10, 15 May 2008, Pages 5570–5583
نویسندگان
Stefanie Libnow, Karen Methling, Martin Hein, Dirk Michalik, Manuela Harms, Kristian Wende, Anke Flemming, Martin Köckerling, Helmut Reinke, Patrick J. Bednarski, Michael Lalk, Peter Langer,