An improved synthesis of arsenic–biotin conjugates

An amide linked conjugate of p-aminophenylarsine oxide and biotin is conveniently prepared in a one-pot procedure by the reaction of biotinyl chloride, formed in situ, with p-aminophenyldichloroarsine. The reaction of the arsine oxide–biotin conjugate with 1,2-ethanedithiol produces the stabilized dithiarsolane. These reagents are now readily available for a variety of applications.

Biotin–arsenic conjugates are prepared conveniently and in good yield directly from p-aminophenyldichloroarsine and biotin.Figure optionsDownload as PowerPoint slide