کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1361019 | 981456 | 2008 | 7 صفحه PDF | دانلود رایگان |
A series of 9 homoserine lactone-derived sulfonylureas substituted by an alkyl chain, some of them bearing a phenyl group at the extremity, have been prepared. All compounds were found to inhibit the action of 3-oxo-hexanoyl-l-homoserine lactone, the natural inducer of bioluminescence in the bacterium Vibrio fischeri, the aliphatic compounds being more active than their phenyl-substituted counterparts. Molecular modelling studies performed on the most active compound in each series suggest that the antagonist activity could be related to the perturbation of the hydrogen-bond network in the ligand–protein complexes.
A series of 9 homoserine lactone-derived sulfonylureas, were prepared and found to inhibit the acyl-homoserine lactones-dependent Vibrio fischeri quorum sensing regulator. Molecular modelling suggested that the inhibitory activity could be related to the perturbation of the hydrogen-bond network in the ligand–protein complexes.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 7, 1 April 2008, Pages 3550–3556