The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki–Miyaura cross-coupling reaction

Novel 3,5-disubstituted ring E analogs of methyllycaconitine were prepared and evaluated in nicotinic acetylcholine receptor binding assays. The desired analogs were prepared through the Suzuki–Miyaura cross-coupling reaction of methyl 5-bromo-nicotinate. The Suzuki–Miyaura cross-coupling reactions of pyridines with electron withdrawing substituents have not been extensively described previously.

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