New triterpenoid saponins with strong α-glucosidase inhibitory activity from the roots of Gypsophila oldhamiana

Seven new triterpenoid saponins (1–7), have been isolated and elucidated from the roots of Gypsophila oldhamiana together with five known triterpenoid saponins (8–12). These saponins which could be classified into three series: 3-O-monoglucosides (1, 8, 9), 28-O-monoglucosides (2–4, 12) and 3, 28-O-bidesmosides (5–7, 10, 11), have been evaluated for their α-glucosidase inhibition activity. As a result, the preliminary structure–activity relationships were discussed based on the position of sugar linkage attached to the aglycone, and 28-O-monoglucosides 2–4 and 12 showed significant inhibitory activities on α-glucosidase.

Seven new triterpenoid saponins have been isolated from the roots of Gypsophila oldhamiana, in which of them 2–4 showed significant inhibitory activities.Figure optionsDownload as PowerPoint slide