Inhibitory property of the Piper betel phenolics against photosensitization-induced biological damages

The Piper betel phenolics, allylpyrocatechol (APC) and chavibetol (CHV), were found to protect photosensitization-mediated lipid peroxidation (LPO) of rat liver mitochondria effectively, APC being significantly more potent. The better activity of APC vis-à-vis CHV could be attributed to its higher reactivity with 1O2, as revealed from the rate constant values of 1O2 quenching by the respective phenolics. APC also prevented the detrimental effects of the Type II photosensitization-induced toxicity to mouse fibroblast L929 cells. The results suggest that APC may play an important role in protecting biological systems against damage, by eliminating 1O2 generated from certain endogenous photosensitizers.

APC and CHV prevented the photosensitized-induced lipid peroxidation of rat liver mitochondria. The better efficacy of APC correlated with its higher reactivity with 1O2. APC was also found to protect the mouse fibroblast L929 cells against photo-toxicity of methylene blue + UVA light.Figure optionsDownload as PowerPoint slide