کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1361205 981458 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel synthesis and pharmacological evaluation of a potential dopamine D1/D2 agonist: 1-Propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,7-diol
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A novel synthesis and pharmacological evaluation of a potential dopamine D1/D2 agonist: 1-Propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,7-diol
چکیده انگلیسی

Previously, we have demonstrated that enone prodrugs of dopaminergic catecholamines represent a new type of dopamine (DA) agonist. Trans-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,7-diol (TL-334), the active form of trans-1-propyl-2,3,4,4a,5,7,8,9,10,10a-decahydro-1H-benzo[g]quinolin-6-one (GMC-6650), in vivo showed an extremely potent dopaminergic activity. Here, we report a novel synthesis and a pharmacological evaluation of TL-334 by means of microdialysis.

1-Propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,7-diol is an extremely potent dopamine receptor agonist. As a catecholamine, this compound is comparable to apomorphine for the treatment of Parkinson’s disease.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 6, 15 March 2008, Pages 3438–3444
نویسندگان
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