کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1361223 | 981459 | 2011 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs)
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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![عکس صفحه اول مقاله: Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs)](/preview/png/1361223.png)
چکیده انگلیسی
A novel class of KAT modulators (long chain alkylidenemalonates, LoCAMs) has been identified. Variations of the alkyl chain length can change the activity profile from inhibition of both KAT3A/KAT2B (as derivative 2a) to the peculiar profile of pentadecylidenemalonate 1b, the first activator/inhibitor of histone acetyltransferases. Together with the powerful apoptotic effect (particularly notable if considering that anacardic acid and other KAT inhibitors are not cell permeable) appoint them as valuable biological tools to understand the mechanisms of lysine acetyltransferases.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 12, 15 June 2011, Pages 3690–3701
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 12, 15 June 2011, Pages 3690–3701
نویسندگان
Ciro Milite, Sabrina Castellano, Rosaria Benedetti, Alessandra Tosco, Carmen Ciliberti, Caterina Vicidomini, Ludovic Boully, Gianluigi Franci, Lucia Altucci, Antonello Mai, Gianluca Sbardella,