کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1361335 | 981461 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives](/preview/png/1361335.png)
چکیده انگلیسی
This study discovered that glycyrrhetinic acid inhibited the human 20S proteasome at 22.3 μM. Esterification of the C-3 hydroxyl group on glycyrrhetinic acid with various carboxylic acid reagents yielded a series of analogs with marked improved potency. Among the derivatives, glycyrrhetinic acid 3-O-isophthalate (17) was the most potent compound with IC50 of 0.22 μM, which was approximately 100-fold more potent than glycyrrhetinic acid.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 14, 15 July 2008, Pages 6696–6701
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 14, 15 July 2008, Pages 6696–6701
نویسندگان
Li Huang, Donglei Yu, Phong Ho, Keduo Qian, Kuo-Hsiung Lee, Chin-Ho Chen,