کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1361341 | 981461 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and biological activity of some new flavonyl-2,4-thiazolidinediones
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A new series of flavonyl-2,4-thiazolidinediones (Va–c, VIa–c) was prepared by Knoevenagel reaction. The synthesized compounds were tested for their ability to inhibit rat kidney aldose reductase (AR) and for their insulinotropic activities in INS-1 cells. Compound Vb was able to increase insulin release in the presence of 5.6 mmol/l glucose. Compounds VIa–c displayed moderate to high AR inhibitory activity levels. Particularly, compound VIa showed the highest AR inhibitory activity (86.57%).
A new series of flavonyl-2,4-thiazolidinediones were prepared by Knoevenagel reaction. The prepared compounds were tested for their aldose reductase inhibitory and insulinotropic activities.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 14, 15 July 2008, Pages 6747–6751
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 14, 15 July 2008, Pages 6747–6751
نویسندگان
Oya Bozdağ-Dündar, Eugen J. Verspohl, Net Daş-Evcimen, Rebecca M. Kaup, Katrin Bauer, Mutlu Sarıkaya, Begüm Evranos, Rahmiye Ertan,