Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres

Aza-analogues of clausine E, mukonine and koenoline were prepared from 1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde and their antiproliferative activity was evaluated against miscellaneous cancer cell lines and compared to those obtained with clausine E and mukonine.

Antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres 1–3 was evaluated against miscellaneous cancer cell lines and compared to those obtained with clausine E and mukonine.Figure optionsDownload as PowerPoint slide