Synthesis of egonol derivatives and their antimicrobial activities

Eighteen derivatives of egonol (A–R) were synthesized and evaluated for their antimicrobial activities against Staphylococcus aureus ATCC 29213, Bacillus subtilis ATCC 6633, Candida albicans ATCC 10231 and Escherichia coli ATCC 8739 microorganisms comparing with egonol. The obtained data reported that compound B exhibited improved activities against all tested bacteria than egonol, others have shown different range of activities.

Eighteen egonol derivatives via substitution, (at C-3, C-6, and C-3″), oxidation, reduction and condensation reactions were synthesized and their antimicrobial activities against four well-known bacterias and yeast were investigated.Figure optionsDownload as PowerPoint slide