کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1361682 981469 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An efficient synthesis of the precursor of AI-2, the signalling molecule for inter-species quorum sensing
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
An efficient synthesis of the precursor of AI-2, the signalling molecule for inter-species quorum sensing
چکیده انگلیسی

Autoinducer-2 (AI-2) is a signalling molecule for bacterial inter-species communication. A synthesis of (S)-4,5-dihydroxypentane-2,3-dione (DPD), the precursor of AI-2, is described starting from methyl glycolate. The key step was an asymmetric reduction of a ketone with (S)-Alpine borane. This new method was highly reproducible affording DPD for biological tests without contaminants. The biological activity was tested with the previously available assays and compared with a new method using an Escherichia coli reporter strain thus avoiding the use of the pathogenic Salmonella reporter.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 3, 1 February 2011, Pages 1236–1241
نویسندگان
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