کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1361803 | 981471 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chemoenzymatic synthesis and antiviral evaluation of conformationally constrained and 3′-methyl-branched carbanucleosides using both enantiomers of the same building block
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Starting from both enantiomers of a readily available building block, a straightforward enantioselective approach to constrained 3′-methyl-2′,3′-α-oxirane-fused and 3′-methyl-3′,4′-α-oxirane-fused carbanucleosides bearing different purine base analogues is described. The title compounds were evaluated as potential antiviral agents against important viruses. None of the new compounds had significant antiviral activity at a concentration of 100 μg/mL, which was the highest concentration tested.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 1, 1 January 2008, Pages 374–381
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 1, 1 January 2008, Pages 374–381
نویسندگان
Yoann Aubin, Gérard Audran, Honoré Monti, Erik De Clercq,