Design of a pyrene-containing fluorescence probe for labeling of RNA poly(A) tracts

A labeling probe containing a pyrenecarboxamide-tethered modified DNA base, PyU, has been developed for fluorometric detection of RNA poly(A) tracts, in which the fluorescence emission intensity was controlled by the microstructural change around PyU caused by binding with the target RNA.

A labeling probe containing a pyrenecarboxamide-tethered modified DNA base has been designed for fluorometric detection of RNA poly(A) tracts.Figure optionsDownload as PowerPoint slide