Novel imidazo[1,2-a]pyrazine derivatives as potent reversible inhibitors of the gastric H+/K+-ATPase

A series of novel 6-substituted imidazo[1,2-a]pyrazines were synthesized via palladium catalyzed amino- or alkoxycarbonylation as key step. The anti-secretory activity of these compounds has been assessed in a binding assay against H+/K+-ATPase from hog gastric mucosa. Some of the compounds proved to be potent inhibitors of the gastric acid pump.

Substituted imidazo[1,2-a]pyrazines were synthesized and evaluated for their anti-secretory activity in a binding assay against H+/K+-ATPase from hog gastric mucosa.Figure optionsDownload as PowerPoint slide