کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1362042 981477 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemoselective synthesis of erythromycin A ketolides substituted in the C10-methyl group
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Chemoselective synthesis of erythromycin A ketolides substituted in the C10-methyl group
چکیده انگلیسی

The substrate for selective substitution in the C10-methyl group in erythromycin A derivatives was 10,11-anhydro-6O-methyl-descladinosylerythromycin. The latter, as an N-oxide, was reacted with NBS in acetic acid to form an allylic acetate. Nucleophilic substitutions and carbylation by Pd-catalysed cross-coupling reactions provided products substituted in the C10-methyl group. Methods for the preparation of 10-methylene derivatives of 11N,12O-cyclocarbamate 3-ketolides are described. The methylene group is part of an α,β-unsaturated carbonyl system involving the 9-keto group. The products from conjugated addition are substituted in the C10-methyl group.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 1, 1 January 2007, Pages 119–129
نویسندگان
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