Design, synthesis, and biological evaluation of novel iso-d-2′,3′-dideoxy-3′-fluorothianucleoside derivatives

Novel iso-d-2′,3′-dideoxythianucleoside derivatives 1-4 were designed and synthesized from d-glucose as a bioisostere of lamivudine. Among compounds tested, cytosine analogue 3 showed a potent anti vesicular stomatitis virus (VSV) activity. This result implies that iso-2′,3′-dideoxy sugar templates might play a role of a sugar surrogate of nucleosides for the development of anti-RNA virus agent.