The triphosphate of β-d-4′-C-ethynyl-2′,3′-dideoxycytidine is the preferred enantiomer substrate for HIV reverse transcriptase

The enantioselective synthesis of the β-d (1) enantiomer of 4′-C-ethynyl-2′,3′-dideoxycytidine confirms an earlier stereochemical assignment that was strictly based on the ability of HIV reverse transcriptase and its M184V mutant to discriminate between the d- and l-configuration of nucleoside 5′-triphosphates.

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