Synthesis and SAR study of novel 7-(pyridinium-3-yl)-carbonyl imidazo[5,1-b]thiazol-2-yl carbapenems

A new series of 1β-methyl carbapenems, possessing a 7-substituted imidazo[5,1-b]thiazol-2-yl group was synthesized and evaluated for antibacterial activity. These compounds showed potent anti-MRSA as well as anti-PRSP and anti-BLNAR activity.