Synthesis and structure-antibacterial activity relationship investigation of isomeric 2,3,5-substituted perhydropyrrolo[3,4-d]isoxazole-4,6-diones

A series of isomeric 2,3,5-substituted perhydropyrrolo[3,4-d]isoxazole-4,6-diones (cis-3a-v and trans-3a-v) were prepared in order to investigate their antibacterial activities. Some of them showed promising activity.