کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1362158 | 981479 | 2010 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
4â³-O-(Ï-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 4â³-O-(Ï-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens 4â³-O-(Ï-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens](/preview/png/1362158.png)
چکیده انگلیسی
Four macrolides-6-O-methyl-8a-aza-8a-homoerythromycin, clarithromycin, azithromycin and azithromycin 11,12-cyclic carbonate, have been selected for the construction of a series of new quinolone derivatives. The quinolone moiety is connected to the macrolide scaffold via a diaminoaklyl 4â³-O-propionyl ester chain of varying length. At the terminus the linker is attached via one of the nitrogen atoms in the linker at C(6) or C(7) of the quinolone. Many of compounds described, particularly clarithromycin derivative 37, and azithromycin derivatives 48 and 55, exhibited excellent antibacterial activity against a wide range of clinically relevant macrolide-resistant organisms, with profiles superior to that of telithromycin, an enhanced spectrum ketolide.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 17, 1 September 2010, Pages 6559-6568
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 17, 1 September 2010, Pages 6559-6568
نویسندگان
A. FajdetiÄ, H. ÄipÄiÄ Paljetak, G. Lazarevski, A. Hutinec, S. AlihodžiÄ, M. Äerek, V. Å timac, D. Andreotti, V. Å unjiÄ, J.M. Berge, S. Mutak, M. DumiÄ, S. Lociuro, D.J. Holmes, N. MarÅ¡iÄ, V. ErakoviÄ Haber, R. Spaventi,