Synthesis, characterization, antibacterial and cytotoxic study of platinum (IV) complexes

Platinum (IV) complexes [Pt (L)2Cl2] [where, L = benzyl-N-thiohydrazide (L1), (benzyl-N-thio)-1,3-propanediamine (L2), benzaldehyde-benzyl-N-thiohydrazone (L3) and salicylaldehyde-benzyl-N-thiohydrazone (L4)] have been synthesized. The thiohydrazide, thiodiamine and thiohydrazones can exist as thione-thiol tautomer and coordinate as a bidentate N–S ligand. The ligands were found to act in monobasic bidentate fashion. Analytical data reveal that metal to ligand stoichiometry is 1:2. The complexes have been characterized by elemental analysis, IR, mass, electronic and 1H NMR spectroscopic studies. In vitro antibacterial and cytotoxic studies have been carried out for some complexes. Various kinetic and thermodynamic parameters like order of reaction (n), activation energy (Ea), apparent activation entropy (S#) and heat of reaction (ΔH) have also been carried out for some complexes.

Platinum (IV) complexes [Pt (L)2Cl2] [where, L = benzyl-N-thiohydrazide (L1), (benzyl-N-thio)-1,3-propanediamine (L2), benzaldehyde-benzyl-N-thiohydrazone (L3) and salicylaldehyde-benzyl-N-thiohydrazone (L4)] have been synthesized. The thiohydrazides, thiodiamine and thiohydrazones can exist as thione-thiol tautomer and coordinate as a bidentate N–S ligand. Platinum (IV) complexes of the thiohydrazide, thiodiamine and thiohydrazones were characterized by elemental analysis, IR, mass, electronic and 1H NMR spectroscopic studies. The complexes were also screened for antibacterial and cytotoxic activity. Thermodynamic parameters such as activation energy (Ea), apparent activation entropy (S#) and enthalpy change (ΔH) for the dehydration and decomposition reactions of the complexes have also been evaluated.Figure optionsDownload as PowerPoint slide