کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1362272 | 981482 | 2006 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes](/preview/png/1362272.png)
چکیده انگلیسی
Based on the structures of several lipophilic trioxolane antimalarial prototypes, we set out to determine which functional groups were associated with good antimalarial profiles and identify more polar (lower Log P/Log D) lead compounds with good physicochemical properties. More lipophilic trioxolanes tended to have better oral activities than their more polar counterparts. Trioxolanes with a wide range of neutral and basic, but not acidic, functional groups had good antimalarial profiles.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 18, 15 September 2006, Pages 6368–6382
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 18, 15 September 2006, Pages 6368–6382
نویسندگان
Yuxiang Dong, Yuanqing Tang, Jacques Chollet, Hugues Matile, Sergio Wittlin, Susan A. Charman, William N. Charman, Josefina Santo Tomas, Christian Scheurer, Christopher Snyder, Bernard Scorneaux, Saroj Bajpai, Scott A. Alexander, Xiaofang Wang,