Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors

Five new structural analogues of substituted-1H-quinolinones (19, 20, 23, 24, and 26) have been synthesized and evaluated for Staphylococcus aureus methionyl-tRNA synthetase enzyme inhibitory activity. These compounds were also tested against pathogens of six S. aureus, two Enterococcus faecalis, and one Enterococcus faecium. Among all the synthesized quinolinones, compound 20 displayed significant inhibitory activities in the strains of E. faecalis and E. faecium.

Synthesis and Staphylococcus aureus methionyl-tRNA synthetase inhibitory activities of substituted-1H-quinolones are described.Figure optionsDownload as PowerPoint slide