The influence of modifications in imide fragment structure on 5-HT1A and 5-HT7 receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines

New, flexible and rigid 1-(m-trifluorophenyl)piperazines with very high affinity and agonistic in vivo activity for 5-HT1A receptors were synthesized. Flexible compounds also bound to 5-HT7 receptors. Two of tested glutarimides demonstrated anxiolytic- and antidepressant-like activity in the pharmacological tests.