Azetidinone-isothiazolidinones: Stereoselective synthesis and antibacterial evaluation of new monocyclic beta-lactams

A simple and efficient procedure for the stereoselective synthesis of new azetidinone-isothiazolidinones has been developed. New compounds were tested in vitro on a panel of Gram-positive and Gram-negative bacterial pathogens, some of them showing weak antibacterial activity.

New azetidinone-isothiazolidinones were prepared from penam amides by a simple and efficient procedure. New compounds were tested on selected bacterial pathogens, some of them showing weak antibacterial activity.Figure optionsDownload as PowerPoint slide