کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1362519 981490 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors
چکیده انگلیسی

The trifluoromethylphenyl P2 motif from previously reported heteroarylnitrile series has been successfully applied for the design and synthesis of highly potent novel ketoamide-based cathepsin S inhibitors. The key in this process is the change of the torsion angle between the P2 phenyl ring and the attached secondary amide by adding a small Cl, F, or Me group at the 2-position.

By using a small atom (Cl, F, or Me) to increase the torsion angle between the phenyl ring and the attached secondary amide, trifluoromethylphenyl motif was applied successfully as P2 for aldehyde/ketoamide-based cathepsin S inhibitors.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 23, 1 December 2010, Pages 6890–6894
نویسندگان
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