کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1362647 | 981493 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Two series of N-[5-oxo-4-(arylsulfonyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]-amides were synthesized and tested in vivo for their analgesic and anti-inflammatory activities. All the new compounds possess good antalgic action in the acetic acid writhing test and some terms of the series showed also fair anti-inflammatory activity in the carrageenan rat paw edema test. Ulcerogenic and irritative action on the gastrointestinal mucose, in comparison with indomethacin is low.
New 2,4-disubstituted 1,3,4-thiadiazole derivatives 3a–t were synthesized and tested for pharmacological actions. Compounds showed interesting analgesic and anti-inflammatory activity in vivo; ulcerogenic action was also reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 6, 15 March 2006, Pages 1698–1705
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 6, 15 March 2006, Pages 1698–1705
نویسندگان
Silvia Schenone, Chiara Brullo, Olga Bruno, Francesco Bondavalli, Angelo Ranise, Walter Filippelli, Barbara Rinaldi, Annalisa Capuano, Giuseppe Falcone,