کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1362684 981493 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibition of cellular proliferation by diterpenes, topoisomerase II inhibitor
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Inhibition of cellular proliferation by diterpenes, topoisomerase II inhibitor
چکیده انگلیسی

We examined the effects of 12 terpene compounds derived from the roots of Euphorbia kansui on the proliferative activity of Xenopus embryo cells. Eight of these compounds showed significant inhibition of cellular proliferation even at low concentrations, while four of them needed to be present at higher concentrations to inhibit cellular proliferation. In order to define the mechanism of inhibition of cellular proliferation by these compounds, the effects of diterpene compounds on the activity of topoisomerase II were measured. Most of the diterpene compounds that inhibited cellular proliferation also inhibited topoisomerase II activity.

We selected terpene compounds having capacities for inhibition of cellular proliferation and topoisomerase II activity by useful inhibition assay method of proliferation using isolated embryonic cells of Xenopus.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 6, 15 March 2006, Pages 2048–2051
نویسندگان
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