Synthesis and cytotoxicity of some biurets against human breast cancer T47D cell line

Design, synthesis and cytotoxicity of several known and novel biurets against human breast cancer T47D cell line in comparison to doxorubicin are described. Biurets incorporating 2-methyl quinoline-4-yl and benzo[d]thiazol-2-ylthio moieties showed higher cytotoxicity and decreased cell viability in a concentration- and time-dependent manner.

Design, synthesis and cytotoxicity of several biurets substituted at N and N′ with different combination of R1 and R2 groups on human breast cancer T47D cell line are described.Figure optionsDownload as PowerPoint slide