کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1362997 981500 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemical investigation of drug-like compounds from the Australian tree, Neolitseadealbata
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Chemical investigation of drug-like compounds from the Australian tree, Neolitseadealbata
چکیده انگلیسی

Two of the four parameters in the ‘rule of five’, molecular weight and log P, which can be detected and predicted by mass spectrometry and compound retention on reversed-phase HPLC, were used as guidelines in natural product isolation. A new aporphine alkaloid, (6aR)-normecambroline (1), was isolated from the bark of Neolitsea dealbata (R. Br.) Merr. Its structure was determined on the basis of NMR, MS and CD analysis. It is the first time the absolute configuration of the roemerine-N-oxide was assigned for both roemerine-Nα-oxide (3) and roemerine-Nβ-oxide (4). Physico-chemical property evaluation demonstrated all alkaloids had no Lipinski violation. Compound 1 inhibited selectively against cervical cancer cells (HeLa) with an IC50 of 4.0 μM.

A new aporphine alkaloid, (6aR)-normecambroline (1), was identified from the bark of Neolitseadealbata. This compound inhibited selectively against HeLa cells with an IC50 of 4.0 μM.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 19, 1 October 2010, Pages 5859–5863
نویسندگان
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