Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides

Two new sesquiterpenes, 10β-methoxymuurolan-4-en-3-one (1) and 10α-methoxycadinan-4-en-3-one (2), were isolated from the root bark of Zanthoxylum ailanthoides. The structures of 1 and 2 were elucidated from spectroscopic data. Sixty-seven compounds obtained from the root bark of the same plant were evaluated for inhibition of HIV replication in H9 lymphocyte cells, and 14 compounds demonstrated significant activity. Among them, decarine, γ-fagarine, and (+)-tembamide were the most potent anti-HIV compounds, with EC50 values of <0.1 μg/mL and TI values of >226, >231, and >215, respectively.

Two new sesquiterpenes, 10β-methoxymuurolan-4-en-3-one (1) and 10α-methoxycadinan-4-en-3-one (2), were isolated from the root bark of Zanthoxylum ailanthoides. Sixty-seven compounds obtained from the same plant were evaluated for inhibition of HIV replication in H9 lymphocyte cells, and 14 compounds demonstrated significant activity. Among them, decarine, γ-fagarine, and (+)-tembamide had EC50 values of <0.1 μg/mL and TI values of >226, >231, and >215, respectively.Figure optionsDownload as PowerPoint slide